The Metabolics Report transforms our understanding of how genes confer metabolic individuality and underpin energy regulation, longevity and healthspan.

Methylation is involved in almost every metabolic process in the body, occurring billions of times every second in our cells and contributing to numerous crucial functions.

Steroid hormones are involved in the regulation of many physiological processes in both men and women, such as the development and function of the reproductive system, metabolism, inflammation and immune system.

Histamine, as a neurotransmitter, communicates messages to and from the brain and nervous system; triggers the release of stomach acid to help digestion; and can be released after stress, injury or allergic reaction as part of the body’s immune response.

Detoxification is the physiological removal of toxic substances from the human body. Substances such as nutrients, food additives, pesticides, medications, air pollutants, alcohol and hormones are transformed from being fat-soluble to water-soluble, allowing them to be more easily excreted from the body.

This foundational test analyses how gene variants can affect food tolerance (and intolerance), appetite control and blood sugar balance, vitamin and mineral needs, detoxification ability, and susceptibility to inflammation and infection.

Oestrogen is one of the two major female sex hormones, but men also require oestrogen for sperm and libido. Oestrogen’s role is to increase the growth and production of cells. It is responsible for the development of the female reproductive system and is involved in maintaining bone density, blood clotting and affects mucous membranes and pelvic muscles.

The nervous system supports the transmission of messages around the mind and body, enabling an individual to respond to their environment, either via excitatory neurotransmitters, or via inhibitory neurotransmitters. In order for us to interact effectively with our environment these must remain in balance.

Thyroid hormones control the metabolism of almost every cell in the body, with wide-ranging metabolic, developmental and cardiovascular effects.

DNA sequencing has opened the door to personalised approaches to health and fitness, enabling a more intelligent approach to training, recovery and performance. In this report, we present elements that have been shown to affect athletic performance.

The Apolipoprotein E (APOE) gene is best known for its role in lipid (fat) metabolism by helping to remove cholesterol from the bloodstream. It can exist in three main forms known as E2, E3 and E4.